Dr. Zhe Wang | m6A and Related Disease | Breakthrough Innovations Laureate Award
physician-in-charge at The First Hospital of Shanxi Medical University, China
Dr. Zhe Wang is currently a postdoctoral researcher at Shanxi Medical University, with a research focus that bridges obstetrics and gynecology with epigenetics. She specializes in the investigation of m6A methylation modification mechanisms in female-related diseases. Her research integrates basic science with clinical application, and she has published several high-impact papers exploring tumor microenvironments, mRNA methylation, and their roles in viral infections and cancer development. Dr. Wang is recognized as a promising young scholar in the field of gynecological research in China.
Profile
Education
Dr. Wang began her academic journey in 2004 at Shanxi Medical University, where she earned her bachelor’s degree in Clinical Medicine in 2009. She then pursued a master’s degree in Biochemistry and Molecular Biology under the supervision of Professor Jun Xie, completing it in 2015. From 2016 to 2019, she undertook her doctoral studies in Obstetrics and Gynecology, mentored by Professor Min Hao. Her doctoral research focused on the molecular mechanisms linking folate metabolism and m6A methylation with HPV infection and cervical cancer.
Experience
Since October 2020, Dr. Wang has been conducting postdoctoral research at Shanxi Medical University, co-mentored by Professors Jun Xie and Sanyuan Zhang. During her postdoctoral period, she has led several research projects investigating the role of m6A methylation enzymes in various cellular and pathological processes, including HPV susceptibility and pulmonary fibrosis induced by COVID-19 infection. These studies have contributed to a deeper understanding of epigenetic regulation and have established her as a skilled and independent researcher.
Research Interest
Dr. Wang’s primary research interests lie in the field of epigenetic regulation, particularly m6A RNA methylation and its involvement in tumorigenesis and viral infections. She is especially interested in how folate metabolism influences cervical cancer development via methylation pathways. Her work aims to clarify molecular mechanisms at the intersection of gene expression regulation and clinical pathology, contributing to the advancement of precision medicine in women’s health.
Award
Throughout her career, Dr. Wang has secured multiple grants at both provincial and national levels, reflecting the significance and innovation of her research. She was awarded the “Third Prize for Outstanding Poster Presentation” at the Obstetrics and Gynecology Physicians Congress held by the Chinese Medical Doctor Association in 2020. Additionally, she has co-invented patents related to epidermal and skin stem cell active compounds and has participated in the development of a cervical cancer prevention and control platform, highlighting her contributions to both academic and translational research.
Publication
Dr. Wang has authored or co-authored several high-impact scientific publications, including the following selected works:
Wang Z et al. Folate inhibits miR-27a-3p expression during cervical carcinoma progression and oncogenic activity in human cervical cancer cells. Biomedicine & Pharmacotherapy, 2020; cited by 35 articles.
Yang JL#, Li JP#, Li SF#, Yang YT… Wang Z*. Effects of HOX family regulator-mediated modification patterns and immunity characteristics on tumor-associated cell types in endometrial cancer. Molecular Biomedicine, 2024; cited by 12 articles.
Wang Z#, Du X#, Zhang P#… Zhang X*, Zhang R*. Single-cell transcriptome profiling of m6A regulator-mediated methylation modification patterns in elderly acute myeloid leukemia patients. Molecular Biomedicine, 2024; cited by 9 articles.
Sun B#, Yang JG#, Wang Z#… Exon junction complexes regulate osteoclast-induced bone resorption by influencing the NFATc1 m6A distribution through the “shield effect”. Clinical and Translational Medicine, 2025; cited by 6 articles.
Liu Y#, Wang Z#* et al. Cell-type-specific mRNA m6A landscape and regulatory mechanisms underlying immune dysregulation of sleep-deprived. Journal of Pineal Research, 2025 (accepted); cited by 4 articles.
Conclusion
In conclusion, Dr. Zhe Wang demonstrates strong academic training and advanced research capabilities in both medical science and molecular biology. Her research exhibits clear focus, scientific rigor, and innovation, especially in the intersection of epigenetics, oncology, and virology. With her continued contributions, Dr. Wang is expected to make further impactful advances in the field of obstetrics and gynecology, bridging scientific discovery and clinical application.